HOME > mice > 129+Ter/Sv-Pros1 K196E NCVC mice
Strain Detail: 129+Ter/Sv-Pros1 K196E NCVC mice
| Strain information |
| Resource No. |
nbio280 |
| Strain name |
129+Ter/Sv-Pros1 K196E NCVC |
| Strain Nomenclature |
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| Common name/Synonyms |
PS-K196E knockin(129) |
| Strain types |
congenic |
| Background strain |
129+Ter/Sv Jcl |
| Institution |
Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute |
| Developer |
Toshiyuki Miyata |
| Depositor |
Toshiyuki Miyata (Contact person: Koichi Kokame) |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
The PS-K196E knockin (129) mice are knock-in mice carrying c.586A>G (p.K196E) mutation introduced in Pros1 locus of 129+Ter/Sv mice by knock-in technology. Pros1 gene encodes a blood coagulation control factor, protein S. |
| Reference(s) |
- Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, and Miyata T. (2015) Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood 126(19):2247-53. [PMID:26251307]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Pros1 E/E homozygous |
| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
Natural mating - perfusion |
| Genotype |
Mix of Pros1 E/E homozygous and heterozygous |
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Please contact us |
| Gene information |
| Mutation types |
knockin |
| Gene symbol |
Pros1 |
| Gene name |
protein S (α) |
| Genotyping information |
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