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Strain Detail: Aars2-flox mice
| Strain information |
| Resource No. |
nbio430 |
| Strain name |
Aars2-flox |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Floxed mice of the Aars2 gene, one of the causative genes for progressive leukoencephalopathy. Two loxPs have been inserted into introns 2 and 4 of the Aars2 gene by genome editing (Cre causes the removal of exons 3-4). The mice are expected to be used as conditional knockout mice in the study of progressive leukoencephalopathy. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Homozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
homozygous sperm x C57BL/6NCr Slc |
| Genotype |
heterozygous |
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
conditional KO |
| Gene symbol |
Aars2 |
| Gene name |
alanyl-tRNA synthetase 2, mitochondrial |
| Genotyping information |
|
