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Strain Detail: Ace2-KO mice
| Strain information |
| Resource No. |
nbio388 |
| Strain name |
Ace2-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Knockout mice of Angiotensin-converting enzyme 2 (Ace2). An entire coding sequence of the Ace2 gene on X chromosome in 57BL/6N mice was removed by CRISPR/Cas9 system using TAKE method with Cas9 proteins and two guide RNAs targeting 5’- and 3’-UTRs of the gene. These mice are useful for studies of hypertension and new coronaviruses. For example, it is possible to cross human Ace2-Tg mice (Ace2-Tg#5，Ace2-Tg#16，Ace2-Tg#17) with the Ace2-KO mice to produce mice whose Ace2 molecules are humans only. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Medium |
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| From other institutions |
Mating System |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
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| Cryopreserved embryo |
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| Live animals |
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