HOME > mice > C57BL/6J-Pros1 KO NCVC mice
Strain Detail: C57BL/6J-Pros1 KO NCVC mice
| Strain information |
| Resource No. |
nbio290 |
| Strain name |
C57BL/6J-Pros1 KO NCVC |
| Strain Nomenclature |
|
| Common name/Synonyms |
PS-KO(B6) |
| Strain types |
mutant |
| Background strain |
C57BL/6J Jms Slc |
| Institution |
Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute |
| Developer |
Toshiyuki Miyata |
| Depositor |
Toshiyuki Miyata (Contact person: Koichi Kokame) |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
The PS-KO(B6) mice are Pros1-deficient C57BL/6 mice. The Pros1 gene encodes a blood coagulation control factor, protein S. Homozygous (total) deficiency in protein S is embryonic lethal, whereas mice with heterozygous deficiency reproduce normally. The strain is useful as a mouse model for protein S deficiency, one of the primary causes for congenital embolism. |
| Reference(s) |
- Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, and Miyata T. (2015) Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood 126(19):2247-53. [PMID:26251307]
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
heterozygous |
| Medium |
FERTIUP |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
IVF |
| Genotype |
Mix of heterozygous and wild-type |
| Medium |
EFS40 |
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Pros1 |
| Gene name |
protein S (α) |
| Genotyping information |
|
