HOME > mice > CBA/J-Pde6bem1 mice
Strain Detail: CBA/J-Pde6bem1 mice
| Strain information |
| Resource No. |
nbio465 |
| Strain name |
CBA/J-Pde6bem1 |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
CBA/J |
| Institution |
Division of Laboratory Animal Resources, National Center for Child Health and Development |
| Developer |
Hideki Tsumura |
| Depositor |
Hideki Tsumura |
| Conditions of distribution |
without conditions: contact us |
| Animal Health Report |
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| Strain description |
Pde6b (Phosphodiesterase 6B) is a gene encoding a subunit of the enzyme PDE6, which plays a crucial role in the retinal visual pathway. Several laboratory mouse strains possess natural mutations in this Pde6b gene (such as C3H/He and CBA/J), exhibiting retinal degeneration. This mouse strain was created to have normal retinas by genetic repair of the Pde6b mutation present in the CBA/J strain, which originally prone to retinal degeneration. This strain serves as a useful normal control for research on retinal degenerative diseases. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Y347Y/Y347Y |
| Medium |
Fertiup |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
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| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knock-in |
| Gene symbol |
Pde6b |
| Gene name |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
| Genotyping information |
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