HOME > mice > CK mice
Strain Detail: CK mice
| Strain information | |
|---|---|
| Resource No. | nbio019 |
| Strain name | CK |
| Strain Nomenclature | |
| Common name/Synonyms | |
| Strain types | mutant |
| Background strain | |
| Institution | National Institutes of Biomedical Innovation, Health and Nutrition (NIBN)(formerly, National Institute of Infectious Diseases) |
| Developer | Junichiro Matsuda |
| Depositor | |
| Conditions of distribution | without conditions: contact us |
| Animal Health Report | |
| Strain description | CK mice were established for research of GM1-gangliosidosis which is human neurological genetic disease. CG mouse is a transgenic mouse overexpressing human normal β-galactosidase (β-Gal) in whole body, which was developed to study GM1-gangliosidosis, a typical human neurological genetic disease. Transgenes are consisted of CAG promoter and human β-Gal cDNA. CG mice also express mouse endogenous β-Gal. CK mice were produced by introducing human normal β-Gal into β-Gal KO (BKO) mice. The CK mouse does not express mouse β-Gal but overexpresses human normal β-Gal. The mouse does not show neurologic symptoms or lipid accumulation. |
| Reference(s) | |
| Resource information | |||
|---|---|---|---|
| Cryopreserved sperm | In-house | Genotype | Tg/+, β-Gal (+/-) |
| Medium | FERTIUP | ||
| From other institutions | Genotype | ||
| Medium | |||
| Cryopreserved embryo | In-house | Mating System | |
| Genotype | Tg/+, β-Gal (+/-), β-Gal (-/-) | ||
| Medium | EFS40 | ||
| From other institutions | Mating System | ||
| Genotype | |||
| Method | |||
| Strain status / Availability | Cryopreserved sperm | Within 1 month | |
| Cryopreserved embryo | Within 1 month | ||
| Live animals | Approx. 2 months | ||
| Gene information | |
|---|---|
| Mutation types | transgenic + knockout |
| Gene symbol | Glb1 |
| Gene name | Galactosidase, beta 1 |
| Genotyping information | |