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Strain Detail: DgkβKO mice

Strain information
Resource No. nbio288
Strain name DgkβKO
Strain Nomenclature DgkbTn(sb-lacZ,GFP)IR3.1Jtak
Common name/Synonyms
Strain types mutant
Background strain C57BL/6J Jcl
Institution Department of Genome Biology, Graduate School of Medicine, Osaka University
Developer Junji Takeda
Depositor Junji Takeda
Conditions of distribution Without conditions:contact us
Animal Health Report
Strain description

The DgkβKO mice are knockout mice deficient for diacylglycerol kinase, beta (Dgkβ) gene. Dgkβ is highly expressed in the neurvous system. The mice show short-term and long-term spatial memory disorders with hyperactivity disorder. The strain was produced by the Sleeping Beauty transposon system.
Reference(s)
  1. Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Morita SY, Shimazawa M, Fukunaga K, Takeda J, Saito N, and Hara H. (2010) Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKβ in neurite spine formation, contributing to cognitive function. PLoS One 5(7):e11602. [PMID:20657643]
  2. Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, Shirai Y, Horie K, Saito N, Takeda J, and Hara H. (2010) Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS One 5(10):e13447. [PMID:20976192]
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System IVF
Genotype Mix of heterozygous and wild-type
Method DAP213
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo Within 1 month
Live animals Please contact us
Gene information
Mutation types knockout (Sleeping beauty transposon method)
Gene symbol Dgkb
Gene name diacylglycerol kinase, beta
Genotyping information