HOME > mice > Ereg −/− mice
Strain Detail: Ereg −/− mice
| Strain information |
| Resource No. |
nbio447 |
| Strain name |
Ereg −/− |
| Strain Nomenclature |
|
| Common name/Synonyms |
Ereg-KO |
| Strain types |
mutant |
| Background strain |
B6N-Tyrc-Brd/BrdCrCrl (B6 Albino) |
| Institution |
Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University |
| Developer |
Michiyuki Matsuda |
| Depositor |
Michiyuki Matsuda |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
There are seven types of ligands that bind to the epidermal growth factor (EGF) receptor, and they are classified into high-affinity molecules (EGF, transforming growth factor α (TGF-α), betacellulin (BTC), heparin-binding EGF-like growth factor (HBEGF)) and low-affinity molecules (epiregulin (EREG), epigen (EPGN), amphiregulin (AREG)). The Ereg-/- mice are knockout mice for the low-affinity ligand EREG, created using genome editing, and were used as a tool to study their involvement in skin wound repair (Ref. 1). |
| Reference(s) |
- Deguchi E, Lin S, Hirayama D, Matsuda K, Tanave A, Sumiyama K, Tsukiji S, Otani T, Furuse M, Sorkin A, Matsuda M, and Terai K. (2024) Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells. Cell Rep 43(11):114986. [PMID:39546398]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
homozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
♂:homoheterozygous or wild x ♀:heterozygous
/ ♂:homozygous x ♀:B6 Albino |
| Genotype |
homozygous or heterozygous / heterzygous |
| Medium |
EFS40 |
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Ereg |
| Gene name |
Epiregulin |
| Genotyping information |
|
