HOME > mice > Fads3 KO mice
Strain Detail: Fads3 KO mice
| Strain information |
| Resource No. |
nbio469 |
| Strain name |
Fads3 KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6J |
| Institution |
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University |
| Developer |
Akio Kihara |
| Depositor |
Akio Kihara |
| Conditions of distribution |
Users shall give an acknowledgment to the depositors when publishing the research results. contact us |
| Animal Health Report |
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| Strain description |
Knockout mice of the Fads3 gene produced by genome editing. Fads3 is a member of the Fatty acid desaturase (Fads) family. Fads3 introduces a cis double bond at the C14 position of the sphingosine portion of sphingosine-containing ceramide to synthesize sphingadien-containing ceramide. Sphingadienes are present in a wide range of tissues, and Fads3 expression is also widespread, but Fads3 knockout mice do not show any noticeable phenotype. |
| Reference(s) |
- Jojima K, Edagawa M, Sawai M, Ohno Y, and Kihara A. (2020) Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3. FASEB J 34(2):3318-3335. [PMID:31916624]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Fads3 |
| Gene name |
fatty acid desaturase 3 |
| Genotyping information |
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