HOME > mice > Far1 KO mice
Strain Detail: Far1 KO mice
| Strain information |
| Resource No. |
nbio479 |
| Strain name |
Far1 KO |
| Strain Nomenclature |
|
| Common name/Synonyms |
|
| Strain types |
mutant |
| Background strain |
C57BL/6J |
| Institution |
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University |
| Developer |
Akio Kihara |
| Depositor |
Akio Kihara |
| Conditions of distribution |
Users shall give an acknowledgment to the depositors when publishing the research results. contact us |
| Animal Health Report |
|
| Strain description |
FAR1 is an isoenzyme of fatty acyl-CoA reductase (FAR), which synthesizes aliphatic alcohols from acyl-CoA. Far1 is expressed throughout the body and is involved in the production of ether lipid species, such as plasmalogens. Many Far1 knockout mice exhibit severe symptoms, including neonatal lethality and reduced body weight. |
| Reference(s) |
- Tamazawa A, Naganuma T, Otsuka K, Takahashi T, Sassa T, and Kihara A. (2025) Fatty acyl-CoA reductase FAR1 is essential for the testicular seminolipid synthesis required for spermatogenesis and male fertility. J Biol Chem 301(6):108538. [PMID:40288649]
- Takahashi T, Otsuka K, Sassa T, and Kihara A. (2025) Acyl-CoA Reductase Mol Cell Biol 45(11):495-510. [PMID:40931707]
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
heterozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
IVF |
| Genotype |
heterozygous or wild-type |
| Medium |
EFS40 |
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Far1 |
| Gene name |
fatty acyl CoA reductase 1 |
| Genotyping information |
|
