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Strain Detail: Hck-KO mice
| Strain information |
| Resource No. |
nbio384 |
| Strain name |
Hck-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Knockout mice of hemopoietic cell kinase (HCK), a protein tyrosine kinase belonging to the Src family. The Hck gene was created by setting gRNAs at two locations, Exon 2 and Exon 6, and deleting the gap between them by genome editing. It is expected to be used as a model for myeloproliferative disorders and pulmonary fibrosis. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
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| Cryopreserved embryo |
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| Live animals |
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| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Hck |
| Gene name |
hemopoietic cell kinase |
| Genotyping information |
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