HOME > mice > B6;Cg-Ins1<em1(C96Y)Okt> mice
Strain Detail: B6;Cg-Ins1<em1(C96Y)Okt> mice
| Strain information |
| Resource No. |
nbio471 |
| Strain name |
B6;Cg-Ins1<em1(C96Y)Okt> |
| Strain Nomenclature |
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| Common name/Synonyms |
Ins1C96Y B6 mice |
| Strain types |
mutant |
| Background strain |
C57BL/6NCr Slc |
| Institution |
Animal Research Facility, Research Institute (NCGMRI), National Center for Global Health and Medicine (NCGM) |
| Developer |
Tadashi Okamura |
| Depositor |
Tadashi Okamura |
| Conditions of distribution |
When publishing research results, users must cite the references specified by the depositor. As these mice were generated using Platinum TALEN technology, they can only be distributed for non-commercial research purposes. contact us |
| Animal Health Report |
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| Strain description |
Mice in which Akita mutation (C96Y) was introduced into the insulin 1 gene via genome editing using TALEN and ssODN. Homozygous mice exhibit hyperglycemia from a young age. Note that natural mating between homozygous males and females may be difficult since homozygous individuals exhibit hyperglycemia. |
| Reference(s) |
- Nakano K, Goto M, Fukuda S, Yanobu-Takanashi R, Yabe SG, Shimizu Y, Sakuma T, Yamamoto T, Shimoda M, Okochi H, Takahashi R, and Okamura T. (2025) A Novel Immunodeficient Hyperglycemic Mouse Carrying the Ins1 Akita Mutation for Xenogeneic Islet Cell Transplantation. Transplantation 109(2):e81-e91. [PMID:39104009]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
homozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
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| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knock-in |
| Gene symbol |
Ins1 |
| Gene name |
Insulin 1 |
| Genotyping information |
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