Strain Detail: LKB1-DN/C mice

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LKB1 is an enzyme regulating the activity of AMP-activated protein kinase (AMPK) family. LKB1-DN mice are transgenic mouse lines with skeletal-muscle-specific overexpression of a dominant negative form of LKB1. The overexpression suppresses the LKB1 activity in the skeletal muscle. Comparison of LKB1-DN mice with AMPK-DN mice (nbio079-082), which show skeletal-muscle-specific suppression of AMPK, and with wild-type mice indicated that LKB1-DN mice showed decrease in endurance during exercise in addition to decreased O₂intake and CO₂excretion. These observations suggest that LKB1 exerts AMPK-independent effect on the diaphragm function and is involved in endurance during exercise, and also in O₂intake. There are two LKB1-DN lines (LKB1-DN/B and LKB1-DN/C) with no apparent difference between them.

1. Miura S, Kai Y, Tadaishi M, Tokutake Y, Sakamoto K, Bruce CR, Febbraio MA, Kita K, Chohnan S, Ezaki O. Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm.Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E213-29.
2. http://dfns.u-shizuoka-ken.ac.jp/labs/nutrbioc/index3.html/Research7.html (in Japanese)