HOME > mice > NDRG4 KO mice
Strain Detail: NDRG4 KO mice
| Strain information |
| Resource No. |
nbio229 |
| Strain name |
NDRG4 KO |
| Strain Nomenclature |
C57BL/6J-Ndrg4tmNCVC |
| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
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| Institution |
Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute |
| Developer |
Toshiyuki Miyata |
| Depositor |
Toshiyuki Miyata (Contact person: Koichi Kokame) |
| Conditions of distribution |
In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
NDRG4 KO mice are knockout mice of Ndrg4 gene. These mice are born normally according to Mendelian inheritance, but they will decrease brain-derived neurotrophic factor (BDNF) in cerebral cortices. Consequently, these mice shows disorders of spatial learning or spatial memory and the reduction of resistance for neuronal death caused by cerebral ischemia. |
| Reference(s) |
- Yamamoto H, Kokame K, Okuda T, Nakajo Y, Yanamoto H, and Miyata T. (2011) NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. J Biol Chem 286(29):26158-65. [PMID:21636852]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Ndrg4 |
| Gene name |
NDRG family member 4 |
| Genotyping information |
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