HOME > mice > PlauS378A/S378A mice
Strain Detail: PlauS378A/S378A mice
| Strain information |
| Resource No. |
nbio431 |
| Strain name |
PlauS378A/S378A |
| Strain Nomenclature |
|
| Common name/Synonyms |
|
| Strain types |
mutant |
| Background strain |
C57BL/6 |
| Institution |
Department of Pharmacology, Hamamatsu University School of Medicine |
| Developer |
Takayuki Iwaki |
| Depositor |
Takayuki Iwaki |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
The Plau gene encodes the urokinase-type plasminogen activator (uPA), a serine protease, and the 378th serine is the active site of the enzyme. This strain has a mutation in which the 378th serine of the Plau gene has been replaced with alanine by genome editing using CRISPR/Cas9. |
| Reference(s) |
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
homozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
♂:homozygous
x ♀:B6J |
| Genotype |
heterozygous |
| Medium |
EFS40 |
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knock-in |
| Gene symbol |
Plau |
| Gene name |
urokinase-type plasminogen activator |
| Genotyping information |
|
