HOME > mice > loxP-Rap1GAPII-Tg mice
Strain Detail: loxP-Rap1GAPII-Tg mice
| Strain information |
| Resource No. |
nbio021 |
| Strain name |
loxP-Rap1GAPII-Tg |
| Strain Nomenclature |
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| Common name/Synonyms |
RapGAP mice |
| Strain types |
mutant |
| Background strain |
C57BL/6Cr Slc |
| Institution |
National Cerebral and Cardiovascular Center |
| Developer |
Naoki Mochizuki |
| Depositor |
Naoki Mochizuki |
| Conditions of distribution |
Only for collaboration with the depositor: contact us |
| Animal Health Report |
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| Strain description |
The loxP-Rap1GAPII-Tg mice are transgenic mice overexpressing FLAG-Tagged human Rap1GAPII. This strain were produced using pCAGNL5 vector and CAG promoter. This strain expresses FLAG-Tagged human Rap1GAPII by mating with Cre expressing mice. Rap1GAPII inhibits low molecular G-protein rap1 activity. |
| Reference(s) |
- Mochizuki N, Ohba Y, Kiyokawa E, Kurata T, Murakami T, Ozaki T, Kitabatake A, Nagashima K, and Matsuda M. (1999) Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi. Nature 400(6747):891-4. [PMID:10476970]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Garnl4 (Rap1Gap2) |
| Gene name |
GTPase activating RANGAP domain-like 4 (RAP1 GTPase activating protein 2) |
| Genotyping information |
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