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Strain Detail: Sftpd-KO mice
| Strain information |
| Resource No. |
nbio386 |
| Strain name |
Sftpd-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Mitsuho Sasaki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Knockout mice of surfactant associated protein D (SFTPD), one of the pulmonary surfactant proteins. They were created by introducing a deletion of 11 bp into Exon 2 of the Sftpd gene by genome editing. SFTPD functions as a surfactant that relieves surface tension in the alveoli and is responsible for innate immunity in the alveoli. It is expected to be used as a model for pulmonary fibrosis. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
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| Cryopreserved embryo |
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| Live animals |
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| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Sftpd |
| Gene name |
surfactant associated protein D |
| Genotyping information |
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