HOME > mice > skDNTRPV2-TG mice
Strain Detail: skDNTRPV2-TG mice
| Strain information |
| Resource No. |
nbio250 |
| Strain name |
skDNTRPV2-TG |
| Strain Nomenclature |
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| Common name/Synonyms |
transgenic mice with skeletal-muscle-specific overexpression of dominant-negative TRPV2 |
| Strain types |
mutant |
| Background strain |
C57BL/6J |
| Institution |
National Cerebral and Cardiovascular Center Research Institute, Department of Molecular Physiology |
| Developer |
Yuko Iwata |
| Depositor |
Yuko Iwata |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
The skDNTRPV2-TG mice are transgenic mice with skeletal-muscle-specific expression of channel-pore mutant proteins (E604K) of transient receptor potential cation channel, subfamily V, member 2 (TRPV2). The mice are useful for studying a role of TRPV2 in skeletal muscles. |
| Reference(s) |
- Iwata Y, Katanosaka Y, Arai Y, Shigekawa M, and Wakabayashi S. (2009) Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models. Hum Mol Genet 18(5):824-34. [PMID:19050039]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Trpv2, ACTA1 |
| Gene name |
mouse transient receptor potential cation channel, subfamily V, member 2; human α-skeletal actin promoter |
| Genotyping information |
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