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Strain Detail: SLW mice

Strain information
Resource No. nbio070
Strain name SLW
Strain Nomenclature
Common name/Synonyms
Strain types congenic
Background strain
Institution Graduate School of Natural Science and Technology, Okayama University
Developer Tetsuo Kunieda
Depositor Tetsuo Kunieda
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

SLW mice are observed chondrodysplasia by mutation on Npr2, a C-Type natriuretic peptide (CNP) receptor gene, and body miniaturization. Thus, almost mice are dead caused by gastrointestinal tract abnormality before and after weaning. This strain is a good model of human chondrodysplasia and it's able to be a model for analysis of gastrointestinal tract function.
Reference(s)
  1. Sogawa C, Tsuji T, Shinkai Y, Katayama K, and Kunieda T. (2007) Short-limbed dwarfism: slw is a new allele of Npr2 causing chondrodysplasia. J. Hered. 98(6):575-80. [PMID:17728275]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types spontaneus mutation
Gene symbol Npr2
Gene name Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
Genotyping information