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Strain Detail: TgG3S mice

Strain information
Resource No. nbio232
Strain name TgG3S
Strain Nomenclature
Common name/Synonyms human Gb3 synthase trangenic mice
Strain types mutant
Background strain
Institution Department of Matrix Medicine, Faculty of Medicine, Oita University
Developer Satoshi Ishii
Depositor Satoshi Ishii
Conditions of distribution without conditions: contact us
Animal Health Report
Strain description

This strain is highly expressing α1,4-galactosyltransferase in every tissue. It's possible to generate mice showed the pathology of Fabry disease by mating between TgG3S mice and α-galactosidase knockout mice.
Reference(s)
  1. Shiozuka C, Taguchi A, Matsuda J, Noguchi Y, Kunieda T, Uchio-Yamada K, Yoshioka H, Hamanaka R, Yano S, Yokoyama S, Mannen K, Kulkarni AB, Furukawa K, and Ishii S. (2011) Increased globotriaosylceramide levels in a transgenic mouse expressing human α1,4-galactosyltransferase and a mouse model for treating Fabry disease. J Biochem 149(2):161-70. [PMID:20961863]
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol A4GALT
Gene name α1,4-galactosyltransferase
Genotyping information