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Strain Detail: Trp53 KO mice
| Strain information |
| Resource No. |
nbio348 |
| Strain name |
Trp53 KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
A mouse strain in which Trp53 is knocked out by genome editing (CRISPR/Cas9). Guide RNAs were set at two locations (Exons 4 and 5) in the Trp53 gene, and a part of the coding sequence was deleted. The strain is expected to be used as a model for oncology and pulmonary fibrosis. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Trp53 |
| Gene name |
transformation related protein 53 |
| Genotyping information |
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