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Strain Detail: B6 Albino-ROCK mice

Strain information
Resource No. nbio437
Strain name B6 Albino-ROCK
Strain Nomenclature B6N-Tyrc-Brd/BrdCrCrl-Tg(Eevee-ROCK)pT2A-4146NES
Common name/Synonyms
Strain types mutant
Background strain B6 Albino
Institution Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University
Developer Michiyuki Matsuda
Depositor Michiyuki Matsuda
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

This strain expresses a CAG-promoter-driven FRET biosensor (cytoplasmic localization type) for monitoring ROCK activity.
Reference(s)
  1. Imanishi A, Ichise H, Fan C, Nakagawa Y, Kuwahara K, Sumiyama K, Matsuda M, and Terai K. (2021) Visualization of Spatially-Controlled Vasospasm by Sympathetic Nerve-Mediated ROCK Activation. Am J Pathol 191(1):194-203. [PMID:33069718]
Resource information
Cryopreserved sperm In-house Genotype fluorescence (+)
Medium Fertiup
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System ♂: fluorescence (+) x ♀:B6 Albino
Genotype fluorescence (+) or wild
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol CFP, YFP
Gene name cyan fluorescent protein, yellow fluorescent protein
Genotyping information

Genotypes are determined by fluorescence on the body surface. Mice carrying the transgene emit the fluorescence of CFP and YFP (around 460 to 560 nm) under the blue light (~450 nm).