HOME > mice > Bloc1s6-KO mice
Strain Detail: Bloc1s6-KO mice
| Strain information |
| Resource No. |
nbio361 |
| Strain name |
Bloc1s6-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
 A mouse strain in which Bloc1s6, one of the genes responsible for Hermansky-Pudlak syndrome (HPS), is knocked out by genome editing (CRISPR/Cas9). It was created by deleting the coding sequence near the 5'-end with two gRNAs to the Bloc1s6 gene. Homozygous KO mice have a paler coat color than C57BL/6N wild-type mice (B6 mice, see photos). The strain is expected to be used as an HPS model. Bloc1s6-KO mice often exhibit torticollis, maybe due to abnormal otolith formation (Erway et al., 1971). |
| Reference(s) |
- Erway LC, Fraser AS, and Hurley LS. (1971) Prevention of congenital otolith defect in pallid mutant mice by manganese supplementation. Genetics 67(1):97-108. [PMID:5559839]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Bloc1s6 |
| Gene name |
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin |
| Genotyping information |
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