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Strain Detail: Delta NHE1-TG mice
| Strain information |
| Resource No. |
nbio231 |
| Strain name |
Delta NHE1-TG |
| Strain Nomenclature |
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| Common name/Synonyms |
ΔNHE1-TG |
| Strain types |
mutant |
| Background strain |
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| Institution |
Department of Molecular Physiology, National Cardiovascular Center Research Institute |
| Developer |
Shigeo Wakabayashi |
| Depositor |
Shigeo Wakabayashi |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. Only for collaboration with the depositor. contact us |
| Animal Health Report |
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| Strain description |
This strain is specifically overexpressing activated NHE1 in myocardia, therefore it's a cardiac hypertrophy and heart failure model triggered by increase of intracellular Na+ concentration by NHE1 activation. NHE1 is a important ion transporter to keep cell homeostasis and a member of Na+/H+ Exchangers (NHE) family. |
| Reference(s) |
- Nakamura TY, Iwata Y, Arai Y, Komamura K, and Wakabayashi S. (2008) Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure. Circ Res 103(8):891-9. [PMID:18776042]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
SLC9A1 |
| Gene name |
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member |
| Genotyping information |
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