HOME > mice > Tg-Alpha-beta Crystallin(Arg120Gly) mice
Strain Detail: Tg-Alpha-beta Crystallin(Arg120Gly) mice
| Strain information |
| Resource No. |
nbio230 |
| Strain name |
Tg-Alpha-beta Crystallin(Arg120Gly) |
| Strain Nomenclature |
|
| Common name/Synonyms |
HSPB5 R120G Tg |
| Strain types |
mutant |
| Background strain |
|
| Institution |
Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University |
| Developer |
Atsushi Sanbe |
| Depositor |
Atsushi Sanbe |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
This strain is desmin-related cardiomyopathy model mice and cardiomyocyte-specifically expressing CryAB (R120G) which is a point mutant of CryAB (also called HSPB), which is one of the low-molecular-weight stress proteins (ref.1). It shows that these mice are palliated symptoms of desmin-related cardiomyopathy and prolonged survival by antianginal drug nicorandil which is a ATP-sensitive potassium channel opener (ref.2). |
| Reference(s) |
- Wang X, Osinska H, Klevitsky R, Gerdes AM, Nieman M, Lorenz J, Hewett T, and Robbins J. (2001) Expression of R120G-αB-crystallin causes aberrant desmin and αB-crystallin aggregation and cardiomyopathy in mice. Circ Res 89(1):84-91. [PMID:11440982]
- Sanbe A, Marunouchi T, Yamauchi J, Tanonaka K, Nishigori H, and Tanoue A. (2011) Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice. PLoS One 6(4):e18922. [PMID:21541347]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
|
| Medium |
FERTIUP |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Cryab |
| Gene name |
crystallin, alpha B |
| Genotyping information |
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