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Strain Detail: p13-KO (C57BL/6J Jms Slc) mice

Strain information
Resource No. nbio432
Strain name p13-KO (C57BL/6J Jms Slc)
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6J Jms Slc
Institution Pharmacology Laboratory, Faculty of Pharmacy, Wakayama Medical University
Developer Norihito Shintani
Depositor Norihito Shintani
Conditions of distribution Users shall cite the literature specified by the depositor (ref. 1) when publishing research results obtained by this resource.
Animal Health Report
Strain description

Knockout mice for the P13 gene (also known as the Fmc1 gene) created by introducing deletions via genome editing. These mice are useful for studying mitochondrial function and have been used to investigate the involvement of mitochondrial function in Parkinson's disease (see Ref.　1). Note: According to the depositor, homozygous mice exhibit testicular and ovarian atrophy (unpublished data). Therefore, heterozygous mice must be used to maintain this strain.
Reference(s)
  1. Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani Y, Shintani N, and Hashimoto H. (2018) Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism. EMBO Rep 19(3):. [PMID:29371327]
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System IVF
Genotype Heterozygous & Wild-type
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol p13 (Fmc1)
Gene name p13 (formation of mitochondrial complex V assembly factor 1)
Genotyping information