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Strain Detail: Translin KO mice

Strain information
Resource No. nbio055
Strain name Translin KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Immunology, National Institute of Infectious Deseases
Developer Masataka Kasai
Depositor Masataka Kasai
Conditions of distribution Only for collaboration with the depositor: contact us
Animal Health Report
Strain description

Translin KO mice are knockout mice deleted for all exons of mouse Translin gene in the genomic DNA (full-length ; 10.5 kb, geneGeneBank X81464).

These mice are observed remarkable lymphopenia in childhood. Then, these mice after approximately 8-10 weeks old are serious bone marrow failure decreasing young myeloid cell and erythroblast in the bone marrow, and observed splenomegaly occurred in chronic myelogenous leukemia or myelofibrosis.
Reference(s)
  1. Fukuda Y, Ishida R, Aoki K, Nakahara K, Takashi T, Mochida K, Suzuki O, Matsuda J, and Kasai M. (2008) Contribution of Translin to hematopoietic regeneration after sublethal ionizing irradiation. Biol. Pharm. Bull. 31(2):207-11. [PMID:18239274]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Tsn
Gene name Translin
Genotyping information